Skip to main content

Process development


 

Our scientists and engineers develop synthetic processes to enable rapid, phase-appropriate product development and commercialization.

Our team has expertise in synthetic organic chemistry, physical organic chemistry and particle engineering. We also have expertise in chromatographic separations from analytical to commercial scale purification.

Our commitment to state-of-the-art development utilizes a wide array of equipment and tools:

  • Reaction kinetics modelling
  • In-line reaction monitoring and particle visualization
  • Flow-chemistry from bench to commercial scale
  • Chemistry automation using Mettler-Toledo Easymax and Optimax systems
  • Process optimization and criticality determination using advanced DoE modelling
  • HPAPI development
  • Thermal hazard assessment utilizing Mettler Toledo RC-1
Labels:

Popular posts from this blog

Polymorph, Salt & Cocrystal Screening

 Selecting the optimal solid form of an API during early drug development can mitigate the risk of failure later in development. This can be achieved through polymorph, salt and cocrystal screening. Polymorph screening  aims to identify all relevant forms of an API, investigate their properties and choose the optimal crystalline form. Polymorphism control is exceptionally important and conducting these screens can help prevent the appearance of new forms in the latter stages of development. We focus on establishing the interconversions between forms, the relative stability of forms and understanding the monotropic or enantiotropic relationship between polymorphs when required. Polymorph screening is a regulatory requirement whether a salt, cocrystal or free form compound is chosen for development. Salt screening  is an approach to quickly identify and assess the salt forms of an API. This allows drug developers to modify the physical properties of an API while preserving ...
Read more